p-Cymene Modulate Oxidative Stress and Inflammation in Murine Macrophages: Potential Implication in Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Atherosclerosis, Inflammation and Oxidative Stress
Atherosclerosis is a focal disease of the arterial wall that leads to cardiovascular disease (CVD), the biggest cause of morbidity and mortality in Western societies. CVD, a group of disorders of the heart and the vasculature, includes atherosclerosis, high blood pressure, coronary heart disease, congestive heart failure, stroke and congenital heart defects. The World Health Organization report...
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RATIONALE Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the progression of human atherosclerosis. However, definitive cell type-specific causation studies in vivo are lacking, and the molecular mechanisms of potential proatherogenic effects remain to be determined. OBJECTIVE Our aims were to assess the importance of macrophage mitoOS in atherogenesis and to explore ...
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The initial event in atherogenesis is the increased transcytosis of low density lipoprotein, and its subsequent deposition, retention and modification in the subendothelium. It is followed by the infiltration of activated inflammatory cells from the coronary circulation into the arterial wall. There they secrete reactive oxygen species (ROS) and produce oxidized lipoproteins capable of inducing...
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The cytotoxic potential of an antipyretic and analgesic drug, acetaminophen (APAP), was evaluated in mouse J774.2 monocyte macrophages. The cytotoxicity of APAP was evaluated by MTT cell viability and apoptosis assays. Based on the cell viability and apoptosis assays, further experiments were designed with a low (1 μmol/ml) and a high (10 μmol/ml) dose treatment of APAP in J774.2 cells. Mitocho...
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Air pollution has been associated with significant adverse health effects leading to increased overall morbidity and mortality of worldwide significance. Epidemiological studies have shown that the largest portion of air pollution-related mortality is due to cardiovascular diseases, predominantly those of ischemic nature. Human studies suggest an association with atherosclerosis and increasing ...
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ژورنال
عنوان ژورنال: Cardiovascular & Hematological Agents in Medicinal Chemistry
سال: 2020
ISSN: 1871-5257
DOI: 10.2174/1871525717666191118112310